Antimicrobial Intervention Chemistry
Antimicrobial substances applied to raw meat and poultry are governed by FSIS Directive 7120.1, Safe and Suitable Ingredients Used in the Production of Meat, Poultry, and Egg Products.
The directive specifies approved substances, permitted concentrations, and use conditions.
Substance | FSIS-approved concentration range | Typical application |
Peracetic acid (PAA) | 220–2000 ppm depending on application | Carcass spray, parts dip, chiller |
Acidified sodium chlorite (ASC) | 500–1200 ppm ClO₂-equivalent, pH 2.5–2.9 | Carcass spray, on-line reprocessing |
Cetylpyridinium chloride (CPC) | 0.3–0.8% by weight | Poultry carcass spray |
Trisodium phosphate (TSP) | 8–12% w/v solution | Poultry carcass immersion |
Chlorine (as hypochlorite) | 20–50 ppm free chlorine | Chiller water |
Lactic acid | 2–5% by weight | Beef carcass spray |
Peroxyacetic acid + octanoic acid blends | Per specific 7120.1 listing | Multi-species carcass |
Concentration at the point of application is a CCP monitoring requirement. Verification by titration or colorimetric test at defined frequency under the HACCP plan.
Compatibility of each substance with dosing equipment materials is documented in the Milton Roy Water Treatment Chemicals Guide.

